Isoform-selective histone deacetylase inhibitors
نویسندگان
چکیده
منابع مشابه
Histone Deacetylase Inhibitors: Structure-Based Modeling and Isoform-Selectivity Prediction
An enhanced version of comparative binding energy (COMBINE) analysis, named COMBINEr, based on both ligand-based and structure-based alignments has been used to build several 3-D QSAR models for the eleven human zinc-based histone deacetylases (HDACs). When faced with an abundance of data from diverse structure-activity sources, choosing the best paradigm for an integrative analysis is difficul...
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ژورنال
عنوان ژورنال: Chemical Society Reviews
سال: 2008
ISSN: 0306-0012,1460-4744
DOI: 10.1039/b703830p